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Lopez 10mg Tablet 1 Strip
Lopez is prescribed for:
- Schizophrenia and related psychoses — managing both positive symptoms (e.g., hallucinations, delusions, agitation) and negative symptoms (e.g., social withdrawal, emotional flatness, reduced speech).
- Bipolar Disorder — effective for treating acute manic or mixed episodes, with or without psychotic features or rapid cycling.
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✅ Description:
Olanzapine is an atypical antipsychotic with broad receptor-binding activity, including:
- Serotonin (5HT2A/2C, 5HT3, 5HT6)
- Dopamine (D1–D5)
- Muscarinic (M1–M5)
- Adrenergic α1 and Histamine H1
Its antipsychotic effect is thought to result from combined dopamine and serotonin receptor antagonism. Olanzapine is well absorbed orally, unaffected by food, and demonstrates no carcinogenic or mutagenic properties.
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✔️ Dosage & Administration of Lopez 10
Schizophrenia & Bipolar Disorder (combo therapy):
Start with 5–10 mg once daily. Adjust as needed up to max 20 mg/day.
Mania (monotherapy):
Start with 15 mg once daily. Adjust based on response up to 20 mg/day.
Olanzapine can be taken with or without food. Taper off gradually before discontinuation.
- Elderly (≥65 years): Start at 5 mg/day
- Hepatic/Renal impairment: Start at 5 mg/day
- Children: Not recommended for children under 18 years
✔️ Side Effects of Lopez 10
- Drowsiness, weight gain
- Increased appetite, dizziness, elevated glucose/triglycerides
- Parkinsonism, akathisia, orthostatic hypotension
- Anticholinergic effects (e.g., dry mouth, constipation)
- Edema, photosensitivity
✔️ Interactions
- May reduce the effects of levodopa/dopamine agonists
- CYP1A2 inducers (e.g., rifampicin, omeprazole) may increase clearance
- CYP1A2 inhibitors may reduce clearance
- Carbamazepine increases Lopez clearance
- Activated charcoal reduces bioavailability
- Use cautiously with CNS depressants and alcohol
✔️ Contraindications
- Known hypersensitivity to Olanzapine
- Narrow-angle glaucoma risk
✔️ Pregnancy & Lactation
- Use only if benefits outweigh risks
- No proven teratogenicity, but avoid breastfeeding while on treatment
✔️ Use Lopez cautiously in:
- Seizure-prone individuals or history of seizures
- Blood disorders, liver impairment, or hepatotoxic drugs
- Elderly patients or those using QT-prolonging medications
- Patients operating heavy machinery or driving
✔️ Storage:
Store below 30°C, away from light and moisture. Keep out of children’s reach.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
